BMS Failed to Meet its Primary Endpoint in P-III (CheckMate -914) Trial for Opdivo (nivolumab) + Yervoy (ipilimumab) as Adjuvant Treatment of Localized Renal Cell Carcinoma
Shots:
- Part A of the P-III (CheckMate -914) trial evaluating Opdivo + Yervoy in patients with localized RCC who have undergone full or partial removal of the kidney & are at mod. or high risk of relapse
- The trial failed to meet its 1EPs of DFS as assessed by BICR & the safety profile was consistent with prior reported studies of the Opdivo + Yervoy in solid tumors. The therapy demonstrated clinical benefits across multiple RCC patient populations incl. Opdivo + Yervoy for untreated, intermediate & poor-risk RCC & for advanced RCC while Opdivo for 2L treatment of advanced or metastatic RCC
- Opdivo or Opdivo + Yervoy is also being studied in combination with novel agents targeting alternative immunomodulatory molecules & pathways for RCC
Ref: Bussinesswire | Image: BMS
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